Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

Selection of aptamers from nucleic acid libraries by in vitro evolution represents a powerful method of identifying high-affinity ligands for a broad range of molecular targets. Nevertheless, a sizeable fraction of proteins remain difficult targets due to inherently limited chemical diversity of nuc...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Davies, Douglas R., Gelinas, Amy D., Zhang, Chi, Rohloff, John C., Carter, Jeffrey D., O’Connell, Daniel, Waugh, Sheela M., Wolk, Steven K., Mayfield, Wesley S., Burgin, Alex B., Edwards, Thomas E., Stewart, Lance J., Gold, Larry, Janjic, Nebojsa, Jarvis, Thale C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523867/
https://ncbi.nlm.nih.gov/pubmed/23139410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213933109
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi