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Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets
Selection of aptamers from nucleic acid libraries by in vitro evolution represents a powerful method of identifying high-affinity ligands for a broad range of molecular targets. Nevertheless, a sizeable fraction of proteins remain difficult targets due to inherently limited chemical diversity of nuc...
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| Autori principali: | , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3523867/ https://ncbi.nlm.nih.gov/pubmed/23139410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213933109 |
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