Modified nucleotides may have enhanced early RNA catalysis

The modern version of the RNA World Hypothesis begins with activated ribonucleotides condensing (nonenzymatically) to make RNA molecules, some of which possess (perhaps slight) catalytic activity. We propose that noncanonical ribonucleotides, which would have been inevitable under prebiotic conditio...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Wolk, Steven K., Mayfield, Wesley S., Gelinas, Amy D., Astling, David, Guillot, Jessica, Brody, Edward N., Janjic, Nebojsa, Gold, Larry
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
Assuntos:
Perspective
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165471/
https://ncbi.nlm.nih.gov/pubmed/32229566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809041117
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