Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

Limited chemical diversity of nucleic acid libraries has long been suspected to be a major constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by EXponential enrichment). Despite this constraint, SELEX has enjoyed considerable success over the past quarter of a centu...

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Main Authors: Rohloff, John C, Gelinas, Amy D, Jarvis, Thale C, Ochsner, Urs A, Schneider, Daniel J, Gold, Larry, Janjic, Nebojsa
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217074/
https://ncbi.nlm.nih.gov/pubmed/25291143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.49
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