Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand

IL-6 is a secreted cytokine that functions through binding two cell surface receptors, IL-6Rα and gp130. Because of its involvement in the progression of several chronic inflammatory diseases, IL-6 is a target of pharmacologic interest. We have recently identified a novel class of ligands called SOM...

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Bibliografiska uppgifter
Huvudupphovsmän: Gelinas, Amy D., Davies, Douglas R., Edwards, Thomas E., Rohloff, John C., Carter, Jeffrey D., Zhang, Chi, Gupta, Shashi, Ishikawa, Yuichi, Hirota, Masao, Nakaishi, Yuichiro, Jarvis, Thale C., Janjic, Nebojsa
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961693/
https://ncbi.nlm.nih.gov/pubmed/24415767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.532697
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