Chemically Modified Interleukin-6 Aptamer Inhibits Development of Collagen-Induced Arthritis in Cynomolgus Monkeys

Interleukin-6 (IL-6) is a potent mediator of inflammatory and immune responses, and a validated target for therapeutic intervention of inflammatory diseases. Previous studies have shown that SL1026, a slow off-rate modified aptamer (SOMAmer) antagonist of IL-6, neutralizes IL-6 signaling in vitro. I...

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Vydáno v:Nucleic Acid Ther
Hlavní autoři: Hirota, Masao, Murakami, Ikuo, Ishikawa, Yuichi, Suzuki, Tomoki, Sumida, Shun-ichiro, Ibaragi, Shigeru, Kasai, Hayato, Horai, Naoto, Drolet, Daniel W., Gupta, Shashi, Janjic, Nebojsa, Schneider, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2016
Témata:
Special Issue on AptamersOriginal Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753578/
https://ncbi.nlm.nih.gov/pubmed/26579954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2015.0567
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