Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

Selection of aptamers from nucleic acid libraries by in vitro evolution represents a powerful method of identifying high-affinity ligands for a broad range of molecular targets. Nevertheless, a sizeable fraction of proteins remain difficult targets due to inherently limited chemical diversity of nuc...

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Main Authors: Davies, Douglas R., Gelinas, Amy D., Zhang, Chi, Rohloff, John C., Carter, Jeffrey D., O’Connell, Daniel, Waugh, Sheela M., Wolk, Steven K., Mayfield, Wesley S., Burgin, Alex B., Edwards, Thomas E., Stewart, Lance J., Gold, Larry, Janjic, Nebojsa, Jarvis, Thale C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523867/
https://ncbi.nlm.nih.gov/pubmed/23139410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213933109
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