Selection of DNA aptamers with two modified bases

The nucleobases comprising DNA and RNA aptamers provide considerably less chemical diversity than protein-based ligands, limiting their versatility. The introduction of novel functional groups at just one of the four bases in modified aptamers has recently led to dramatic improvement in the success...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Gawande, Bharat N., Rohloff, John C., Carter, Jeffrey D., von Carlowitz, Ira, Zhang, Chi, Schneider, Daniel J., Janjic, Nebojsa
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2017
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358403/
https://ncbi.nlm.nih.gov/pubmed/28265062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615475114
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