Selection of DNA aptamers with two modified bases

The nucleobases comprising DNA and RNA aptamers provide considerably less chemical diversity than protein-based ligands, limiting their versatility. The introduction of novel functional groups at just one of the four bases in modified aptamers has recently led to dramatic improvement in the success...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Gawande, Bharat N., Rohloff, John C., Carter, Jeffrey D., von Carlowitz, Ira, Zhang, Chi, Schneider, Daniel J., Janjic, Nebojsa
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358403/
https://ncbi.nlm.nih.gov/pubmed/28265062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615475114
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