Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

The Mre11/Rad50/NBS1 (MRN) complex is thought to be a critical sensor that detects damaged DNA and recruits ATM to DNA foci for activation. However, it remains to be established how the MRN complex regulates ATM recruitment to the DNA foci during DNA double-strand breaks (DSBs). Here we show that Sk...

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Autori principali: Wu, Juan, Zhang, Xian, Zhang, Ling, Wu, Ching-Yuan, Rezaeian, Abdol Hossein, Chan, Chia-Hsin, Li, Ju-Mei, Wang, Jing, Gao, Yuan, Han, Fei, Jeong, Yun Seong, Yuan, Xiandao, Khanna, Kum Kum, Jin, Jianping, Zeng, Yi-Xin, Lin, Hui-Kuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518281/
https://ncbi.nlm.nih.gov/pubmed/22464731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.02.018
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