Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex

Skp2 SCF complex displays E3 ligase activity and oncogenic activity by regulating protein ubiquitination and degradation, in turn regulating cell cycle entry, senescence and tumorigenesis. The maintenance of the integrity of Skp2 SCF complex is critical for its E3 ligase activity. The Skp2 F-box pro...

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Main Authors: Wu, Juan, Lee, Szu-Wei, Zhang, Xian, Han, Fei, Kwan, Suet-Yan, Yuan, Xiandao, Yang, Wei-Lei, Jeong, Yung Seong, Rezaeian, Abdol Hossein, Gao, Yuan, Zeng, Yi-Xin, Lin, Hui-Kuan
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536937/
https://ncbi.nlm.nih.gov/pubmed/22310285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.26
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