Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

The Mre11/Rad50/NBS1 (MRN) complex is thought to be a critical sensor that detects damaged DNA and recruits ATM to DNA foci for activation. However, it remains to be established how the MRN complex regulates ATM recruitment to the DNA foci during DNA double-strand breaks (DSBs). Here we show that Sk...

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Detalhes bibliográficos
Main Authors: Wu, Juan, Zhang, Xian, Zhang, Ling, Wu, Ching-Yuan, Rezaeian, Abdol Hossein, Chan, Chia-Hsin, Li, Ju-Mei, Wang, Jing, Gao, Yuan, Han, Fei, Jeong, Yun Seong, Yuan, Xiandao, Khanna, Kum Kum, Jin, Jianping, Zeng, Yi-Xin, Lin, Hui-Kuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518281/
https://ncbi.nlm.nih.gov/pubmed/22464731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.02.018
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