Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino acid-dependent mTORC1 hyperactivation by recruiting GATOR1

The regulation of RagA(GTP) is important for amino acid-induced mTORC1 activation. Although GATOR1 complex has been identified as a negative regulator for mTORC1 by hydrolyzing RagA(GTP), how GATOR1 is recruited to RagA to attenuate mTORC1 signaling remains unclear. Moreover, how mTORC1 signaling is...

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Publicado no:Mol Cell
Main Authors: Jin, Guoxiang, Lee, Szu-Wei, Zhang, Xian, Cai, Zhen, Gao, Yuan, Chou, Ping-Chieh, Rezaeian, Abdol Hossein, Han, Fei, Wang, Chi-Yun, Yao, Juo-Chin, Gong, Zhaohui, Chan, Chia-Hsin, Tu, Shih-Hsin, Wu, Chih-Hsiung, Sarbassov, Dos D., Ho, Yuan-Soon, Lin, Hui-Kuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476372/
https://ncbi.nlm.nih.gov/pubmed/26051179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.05.010
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