Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts

Cataracts are a significant public health problem with no proven methods for prevention. Discovery of novel disease mechanisms to delineate new therapeutic targets is of importance in cataract prevention and therapy. Herein, we report that mutations in the RagA GTPase (RRAGA), a key regulator of the...

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Udgivet i:PLoS Genet
Main Authors: Chen, Jian-Huan, Huang, Chukai, Zhang, Bining, Yin, Shengjie, Liang, Jiajian, Xu, Ciyan, Huang, Yuqiang, Cen, Ling-Ping, Ng, Tsz-Kin, Zheng, Ce, Zhang, Shaobin, Chen, Haoyu, Pang, Chi-Pui, Zhang, Mingzhi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905677/
https://ncbi.nlm.nih.gov/pubmed/27294265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006090
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