Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts

Cataracts are a significant public health problem with no proven methods for prevention. Discovery of novel disease mechanisms to delineate new therapeutic targets is of importance in cataract prevention and therapy. Herein, we report that mutations in the RagA GTPase (RRAGA), a key regulator of the...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Chen, Jian-Huan, Huang, Chukai, Zhang, Bining, Yin, Shengjie, Liang, Jiajian, Xu, Ciyan, Huang, Yuqiang, Cen, Ling-Ping, Ng, Tsz-Kin, Zheng, Ce, Zhang, Shaobin, Chen, Haoyu, Pang, Chi-Pui, Zhang, Mingzhi
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905677/
https://ncbi.nlm.nih.gov/pubmed/27294265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006090
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