Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction

The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell survival and autophagy, and its activity is regulated by amino acid availability. Rag GTPase-GATOR1 interactions inhibit mTORC1 in the absence of amino acids, and GATOR1 release and activation of RagA/B promotes mTORC1 activity in...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pal, Rituraj, Palmieri, Michela, Chaudhury, Arindam, Klisch, Tiemo Jürgen, di Ronza, Alberto, Neilson, Joel R., Rodney, George G., Sardiello, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195609/
https://ncbi.nlm.nih.gov/pubmed/30341294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06844-4
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