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Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell survival and autophagy, and its activity is regulated by amino acid availability. Rag GTPase-GATOR1 interactions inhibit mTORC1 in the absence of amino acids, and GATOR1 release and activation of RagA/B promotes mTORC1 activity in...
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| Yayımlandı: | Nat Commun |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6195609/ https://ncbi.nlm.nih.gov/pubmed/30341294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06844-4 |
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