miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

HOXA9 and MEIS1 have essential oncogenic roles in mixed lineage leukaemia (MLL)-rearranged leukaemia. Here we show that they are direct targets of miRNA-196b, a microRNA (miRNA) located adjacent to and co-expressed with HOXA9, in MLL-rearranged leukaemic cells. Forced expression of miR-196b signific...

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Autori principali: Li, Zejuan, Huang, Hao, Chen, Ping, He, Miao, Li, Yuanyuan, Arnovitz, Stephen, Jiang, Xi, He, Chunjiang, Hyjek, Elizabeth, Zhang, Jun, Zhang, Zhiyu, Elkahloun, Abdel, Cao, Donglin, Shen, Chen, Wunderlich, Mark, Wang, Yungui, Neilly, Mary Beth, Jin, Jie, Wei, Minjie, Lu, Jun, Valk, Peter J.M., Delwel, Ruud, Lowenberg, Bob, Le Beau, Michelle M., Vardiman, James, Mulloy, James C., Zeleznik-Le, Nancy J., Liu, Paul P., Zhang, Jiwang, Chen, Jianjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514459/
https://ncbi.nlm.nih.gov/pubmed/22353710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1681
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