PBX3 and MEIS1 cooperate in hematopoietic cells to drive acute myeloid leukemias characterized by a core transcriptome of the MLL-rearranged disease

Overexpression of HOXA/MEIS1/PBX3 homeobox genes is the hallmark of mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML). HOXA9 and MEIS1 are considered to be the most critical targets of MLL fusions and their co-expression rapidly induces AML. MEIS1 and PBX3 are not individually abl...

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Vydáno v:Cancer Res
Hlavní autoři: Li, Zejuan, Chen, Ping, Su, Rui, Hu, Chao, Li, Yuanyuan, Elkahloun, Abdel G., Zuo, Zhixiang, Gurbuxani, Sandeep, Arnovitz, Stephen, Weng, Hengyou, Wang, Yungui, Li, Shenglai, Huang, Hao, Neilly, Mary Beth, Wang, Gang Greg, Jiang, Xi, Liu, Paul P., Jin, Jie, Chen, Jianjun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810030/
https://ncbi.nlm.nih.gov/pubmed/26747896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1566
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