PBX3 and MEIS1 cooperate in hematopoietic cells to drive acute myeloid leukemias characterized by a core transcriptome of the MLL-rearranged disease

Overexpression of HOXA/MEIS1/PBX3 homeobox genes is the hallmark of mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML). HOXA9 and MEIS1 are considered to be the most critical targets of MLL fusions and their co-expression rapidly induces AML. MEIS1 and PBX3 are not individually abl...

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Pubblicato in:Cancer Res
Autori principali: Li, Zejuan, Chen, Ping, Su, Rui, Hu, Chao, Li, Yuanyuan, Elkahloun, Abdel G., Zuo, Zhixiang, Gurbuxani, Sandeep, Arnovitz, Stephen, Weng, Hengyou, Wang, Yungui, Li, Shenglai, Huang, Hao, Neilly, Mary Beth, Wang, Gang Greg, Jiang, Xi, Liu, Paul P., Jin, Jie, Chen, Jianjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810030/
https://ncbi.nlm.nih.gov/pubmed/26747896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1566
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