Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML

Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated...

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Hauptverfasser: Li, Zejuan, Huang, Hao, Li, Yuanyuan, Jiang, Xi, Chen, Ping, Arnovitz, Stephen, Radmacher, Michael D., Maharry, Kati, Elkahloun, Abdel, Yang, Xinan, He, Chunjiang, He, Miao, Zhang, Zhiyu, Dohner, Konstanze, Neilly, Mary Beth, Price, Colles, Lussier, Yves A., Zhang, Yanming, Larson, Richard A., Le Beau, Michelle M., Caligiuri, Michael A., Bullinger, Lars, Valk, Peter J. M., Delwel, Ruud, Lowenberg, Bob, Liu, Paul P., Marcucci, Guido, Bloomfield, Clara D., Rowley, Janet D., Chen, Jianjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311258/
https://ncbi.nlm.nih.gov/pubmed/22251480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-386235
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