Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML

Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated...

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Detalhes bibliográficos
Main Authors: Li, Zejuan, Huang, Hao, Li, Yuanyuan, Jiang, Xi, Chen, Ping, Arnovitz, Stephen, Radmacher, Michael D., Maharry, Kati, Elkahloun, Abdel, Yang, Xinan, He, Chunjiang, He, Miao, Zhang, Zhiyu, Dohner, Konstanze, Neilly, Mary Beth, Price, Colles, Lussier, Yves A., Zhang, Yanming, Larson, Richard A., Le Beau, Michelle M., Caligiuri, Michael A., Bullinger, Lars, Valk, Peter J. M., Delwel, Ruud, Lowenberg, Bob, Liu, Paul P., Marcucci, Guido, Bloomfield, Clara D., Rowley, Janet D., Chen, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311258/
https://ncbi.nlm.nih.gov/pubmed/22251480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-386235
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