Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

BACKGROUND: Cell-to-cell variability in protein expression can be large, and its propagation through signaling networks affects biological outcomes. Here, we apply deterministic and probabilistic models and biochemical measurements to study how network topologies and cell-to-cell protein abundance v...

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Main Authors: Birtwistle, Marc R, Rauch, Jens, Kiyatkin, Anatoly, Aksamitiene, Edita, Dobrzyński, Maciej, Hoek, Jan B, Kolch, Walter, Ogunnaike, Babatunde A, Kholodenko, Boris N
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484110/
https://ncbi.nlm.nih.gov/pubmed/22920937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-109
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