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PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells

We explored the crosstalk between cell survival (phosphatidylinositol 3-kinase (PI3K)/Akt) and mitogenic (Ras/Raf/MEK/extracellular signal-regulated kinase (ERK)) signaling pathways activated by an epidermal growth factor (EGF) and analyzed their sensitivity to small molecule inhibitors in the PI3K-...

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Hauptverfasser:	Aksamitiene, Edita, Kholodenko, Boris N., Kolch, Walter, Hoek, Jan B., Kiyatkin, Anatoly
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	2010
Schlagworte:	Article
Online Zugang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2893265/ https://ncbi.nlm.nih.gov/pubmed/20471474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.05.006
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PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells

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