PIK3CA(H1047R) and Her2 initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling

Human breast cancers that have HER2 amplification/overexpression frequently carry PIK3CA mutations, and are often associated with a worse prognosis. However, the role of PIK3CA mutations in the initiation and maintenance of these breast cancers remains elusive. In the present study, we generated a c...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Cheng, Hailing, Liu, Pixu, Ohlson, Carolynn, Xu, Erbo, Symonds, Lynn, Isabella, Adam, Muller, William J., Lin, Nancy U., Krop, Ian E., Roberts, Thomas M., Winer, Eric P., Arteaga, Carlos L., Zhao, Jean J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896860/
https://ncbi.nlm.nih.gov/pubmed/26640141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.377
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados