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PIK3CA(H1047R)-induced paradoxical ERK activation results in resistance to BRAF(V600E) specific inhibitors in BRAF(V600E) PIK3CA(H1047R) double mutant thyroid tumors
Thyroid carcinomas are the most prevalent endocrine cancers. The BRAF(V600E) mutation is found in 40% of the papillary type and 25% of the anaplastic type. BRAF(V600E) inhibitors have shown great success in melanoma but, they have been, to date, less successful in thyroid cancer. About 50% of anapla...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Oncotarget |
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| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Impact Journals LLC
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5732722/ https://ncbi.nlm.nih.gov/pubmed/29262556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21732 |
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