PIK3CA(H1047R)-induced paradoxical ERK activation results in resistance to BRAF(V600E) specific inhibitors in BRAF(V600E) PIK3CA(H1047R) double mutant thyroid tumors

Thyroid carcinomas are the most prevalent endocrine cancers. The BRAF(V600E) mutation is found in 40% of the papillary type and 25% of the anaplastic type. BRAF(V600E) inhibitors have shown great success in melanoma but, they have been, to date, less successful in thyroid cancer. About 50% of anapla...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Oncotarget
मुख्य लेखकों: Roelli, Matthias A., Ruffieux-Daidié, Dorothée, Stooss, Amandine, ElMokh, Oussama, Phillips, Wayne A., Dettmer, Matthias S., Charles, Roch-Philippe
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Impact Journals LLC 2017
विषय:
Research Paper
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732722/
https://ncbi.nlm.nih.gov/pubmed/29262556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21732
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