PIK3CA(H1047R)-induced paradoxical ERK activation results in resistance to BRAF(V600E) specific inhibitors in BRAF(V600E) PIK3CA(H1047R) double mutant thyroid tumors

Thyroid carcinomas are the most prevalent endocrine cancers. The BRAF(V600E) mutation is found in 40% of the papillary type and 25% of the anaplastic type. BRAF(V600E) inhibitors have shown great success in melanoma but, they have been, to date, less successful in thyroid cancer. About 50% of anapla...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Roelli, Matthias A., Ruffieux-Daidié, Dorothée, Stooss, Amandine, ElMokh, Oussama, Phillips, Wayne A., Dettmer, Matthias S., Charles, Roch-Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732722/
https://ncbi.nlm.nih.gov/pubmed/29262556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21732
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