PIK3CA(H1047R)-induced paradoxical ERK activation results in resistance to BRAF(V600E) specific inhibitors in BRAF(V600E) PIK3CA(H1047R) double mutant thyroid tumors

Thyroid carcinomas are the most prevalent endocrine cancers. The BRAF(V600E) mutation is found in 40% of the papillary type and 25% of the anaplastic type. BRAF(V600E) inhibitors have shown great success in melanoma but, they have been, to date, less successful in thyroid cancer. About 50% of anapla...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Roelli, Matthias A., Ruffieux-Daidié, Dorothée, Stooss, Amandine, ElMokh, Oussama, Phillips, Wayne A., Dettmer, Matthias S., Charles, Roch-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732722/
https://ncbi.nlm.nih.gov/pubmed/29262556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21732
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