Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin

Cancer cells expressing constitutively active phosphatidylinositol-3 kinase (PI3K) are proliferative regardless of the absence of insulin, and they form dietary restriction (DR)-resistant tumors in vivo. Because the binding of insulin to its receptors activates the PI3K/AKT/mammalian target of rapam...

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Main Authors: Cufí, Sílvia, Corominas-Faja, Bruna, Lopez-Bonet, Eugeni, Bonavia, Rosa, Pernas, Sonia, López, Isabel álvarez, Dorca, Joan, Martínez, Susana, López, Norberto Batista, Fernández, Severina Domínguez, Cuyàs, Elisabet, Visa, Joana, Rodríguez-Gallego, Esther, Quirantes-Piné, Rosa, Segura-Carretero, Antonio, Joven, Jorge, Martin-Castillo, Begoña, Menendez, Javier A.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2013
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824528/
https://ncbi.nlm.nih.gov/pubmed/23986086
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