Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations

Oncogenic mutations in PIK3CA, which encodes the phosphoinositide-3-kinase (PI3K) catalytic subunit p110α, occur in ∼25% of human breast cancers. In this study, we report the development of a knock-in mouse model for breast cancer where the endogenous Pik3ca allele was modified to allow tissue-speci...

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Detalhes bibliográficos
Main Authors: Yuan, W, Stawiski, E, Janakiraman, V, Chan, E, Durinck, S, Edgar, K A, Kljavin, N M, Rivers, C S, Gnad, F, Roose-Girma, M, Haverty, P M, Fedorowicz, G, Heldens, S, Soriano, R H, Zhang, Z, Wallin, J J, Johnson, L, Merchant, M, Modrusan, Z, Stern, H M, Seshagiri, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3550595/
https://ncbi.nlm.nih.gov/pubmed/22370636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.53
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