PIK3CA(H1047R) and Her2 initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling

Human breast cancers that have HER2 amplification/overexpression frequently carry PIK3CA mutations, and are often associated with a worse prognosis. However, the role of PIK3CA mutations in the initiation and maintenance of these breast cancers remains elusive. In the present study, we generated a c...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Cheng, Hailing, Liu, Pixu, Ohlson, Carolynn, Xu, Erbo, Symonds, Lynn, Isabella, Adam, Muller, William J., Lin, Nancy U., Krop, Ian E., Roberts, Thomas M., Winer, Eric P., Arteaga, Carlos L., Zhao, Jean J.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896860/
https://ncbi.nlm.nih.gov/pubmed/26640141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.377
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