Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers

Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-α catalytic subunit (PIK3CA) 1. They are most frequently observed in two hotspots: the helical domain (E545K and E542K) and the kinase domain (H1047R). Although the PIK3CA mutants are transforming in vi...

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Main Authors: Engelman, Jeffrey A., Chen, Liang, Tan, Xiaohong, Crosby, Katherine, Guimaraes, Alexander R., Upadhyay, Rabi, Maira, Michel, McNamara, Kate, Perera, Samanthi A., Song, Youngchul, Chirieac, Lucian R., Kaur, Ramneet, Lightbown, Angela, Simendinger, Jessica, Li, Timothy, Padera, Robert F., García-Echeverría, Carlos, Weissleder, Ralph, Mahmood, Umar, Cantley, Lewis C., Wong, Kwok-Kin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683415/
https://ncbi.nlm.nih.gov/pubmed/19029981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1890
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