Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

BACKGROUND: Cell-to-cell variability in protein expression can be large, and its propagation through signaling networks affects biological outcomes. Here, we apply deterministic and probabilistic models and biochemical measurements to study how network topologies and cell-to-cell protein abundance v...

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Bibliografski detalji
Glavni autori: Birtwistle, Marc R, Rauch, Jens, Kiyatkin, Anatoly, Aksamitiene, Edita, Dobrzyński, Maciej, Hoek, Jan B, Kolch, Walter, Ogunnaike, Babatunde A, Kholodenko, Boris N
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484110/
https://ncbi.nlm.nih.gov/pubmed/22920937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-109
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