SCAFFOLDING PROTEIN GAB1 SUSTAINS EPIDERMAL GROWTH FACTOR-INDUCED MITOGENIC AND SURVIVAL SIGNALING BY MULTIPLE POSITIVE FEEDBACK LOOPS

Grb2-associated binder 1 (GAB1) is a scaffold protein involved in numerous interactions that propagate signaling by growth factor and cytokine receptors. Here we explore in silico and validate in vivo the role of GAB1 in the control of mitogenic (Ras/MAPK) and survival (PI3K/Akt) signaling stimulate...

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Hauptverfasser: Kiyatkin, Anatoly, Aksamitiene, Edita, Markevich, Nick I., Borisov, Nikolay M., Hoek, Jan B., Kholodenko, Boris N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2312093/
https://ncbi.nlm.nih.gov/pubmed/16687399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M600482200
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