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Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses
We show theoretically and experimentally a mechanism behind the emergence of wide or bimodal protein distributions in biochemical networks with nonlinear input–output characteristics (the dose–response curve) and variability in protein abundance. Large cell-to-cell variation in the nonlinear dose–re...
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| Publicado no: | J R Soc Interface |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4233687/ https://ncbi.nlm.nih.gov/pubmed/24966234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2014.0383 |
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