Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

We show theoretically and experimentally a mechanism behind the emergence of wide or bimodal protein distributions in biochemical networks with nonlinear input–output characteristics (the dose–response curve) and variability in protein abundance. Large cell-to-cell variation in the nonlinear dose–re...

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Detalhes bibliográficos
Publicado no:J R Soc Interface
Main Authors: Dobrzyński, Maciej, Nguyen, Lan K., Birtwistle, Marc R., von Kriegsheim, Alexander, Blanco Fernández, Alfonso, Cheong, Alex, Kolch, Walter, Kholodenko, Boris N.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233687/
https://ncbi.nlm.nih.gov/pubmed/24966234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2014.0383
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