Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modeling, mass spectrometry-based quantitation of network components, and experimental validation in MDA-MB-231 mesenchymal breast can...

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Udgivet i:Cell Syst
Main Authors: Byrne, Kate M., Monsefi, Naser, Dawson, John C., Degasperi, Andrea, Bukowski-Wills, Jimi-Carlo, Volinsky, Natalia, Dobrzyński, Maciej, Birtwistle, Marc R., Tsyganov, Mikhail A., Kiyatkin, Anatoly, Kida, Katarzyna, Finch, Andrew J., Carragher, Neil O., Kolch, Walter, Nguyen, Lan K., von Kriegsheim, Alex, Kholodenko, Boris N.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802415/
https://ncbi.nlm.nih.gov/pubmed/27136688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.01.003
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