Hypoxic induction of vasculogenic mimicry in hepatocellular carcinoma: role of HIF-1 α, RhoA/ROCK and Rac1/PAK signaling

BACKGROUND: Vasculogenic mimicry (VM), defined as a capability of aggressive tumor Cells to mimic embryonic vasculogenic networks, caused poor prognosis in hepatocellular carcinoma (HCC). Rho kinases (ROCK), p21-activated kinase (PAK), hypoxia or epithelial-mesenchymal transition (EMT) contributed t...

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Vydáno v:BMC Cancer
Hlavní autoři: Zhang, Ji-Gang, Zhou, He-Ming, Zhang, Xue, Mu, Wan, Hu, Juan-Ni, Liu, Gao-Lin, Li, Qin
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6958789/
https://ncbi.nlm.nih.gov/pubmed/31931758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6501-8
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