Hypoxic induction of vasculogenic mimicry in hepatocellular carcinoma: role of HIF-1 α, RhoA/ROCK and Rac1/PAK signaling

BACKGROUND: Vasculogenic mimicry (VM), defined as a capability of aggressive tumor Cells to mimic embryonic vasculogenic networks, caused poor prognosis in hepatocellular carcinoma (HCC). Rho kinases (ROCK), p21-activated kinase (PAK), hypoxia or epithelial-mesenchymal transition (EMT) contributed t...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Zhang, Ji-Gang, Zhou, He-Ming, Zhang, Xue, Mu, Wan, Hu, Juan-Ni, Liu, Gao-Lin, Li, Qin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6958789/
https://ncbi.nlm.nih.gov/pubmed/31931758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6501-8
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