HIF-1α promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment

BACKGROUND: The incidence and mortality rates of hepatocellular carcinoma (HCC) have steadily increased in recent years. A hypoxic microenvironment is one of the most important characteristics of solid tumors which has been shown to promote tumor metastasis, epithelial-mesenchymal transition and ang...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Wang, Meili, Zhao, Xiulan, Zhu, Dongwang, Liu, Tieju, Liang, Xiaohui, Liu, Fang, Zhang, Yanhui, Dong, Xueyi, Sun, Baocun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408450/
https://ncbi.nlm.nih.gov/pubmed/28449718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0533-1
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