Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia

Expression of microRNAs (miRNAs) is under stringent regulation at both transcriptional and post-transcriptional levels. Disturbance at either level could cause dysregulation of miRNAs. Here we show that MLL fusion proteins negatively regulate production of miR-150, an miRNA widely repressed in acute...

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מידע ביבליוגרפי
Main Authors: Jiang, Xi, Huang, Hao, Li, Zejuan, Li, Yuanyuan, Wang, Xiao, Gurbuxani, Sandeep, Chen, Ping, He, Chunjiang, You, Dewen, Zhang, Shuodan, Wang, Jinhua, Arnovitz, Stephen, Elkahloun, Abdel, Price, Colles, Hong, Gia-Ming, Ren, Haomin, Kunjamma, Rejani B., Neilly, Mary Beth, Matthews, Jono, Xu, Mengyi, Larson, Richard A., Le Beau, Michelle M., Slany, Robert K., Liu, Paul P., Lu, Jun, Zhang, Jiwang, He, Chuan, Chen, Jianjun
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480215/
https://ncbi.nlm.nih.gov/pubmed/23079661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.08.028
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