Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia

Expression of microRNAs (miRNAs) is under stringent regulation at both transcriptional and post-transcriptional levels. Disturbance at either level could cause dysregulation of miRNAs. Here we show that MLL fusion proteins negatively regulate production of miR-150, an miRNA widely repressed in acute...

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Главные авторы: Jiang, Xi, Huang, Hao, Li, Zejuan, Li, Yuanyuan, Wang, Xiao, Gurbuxani, Sandeep, Chen, Ping, He, Chunjiang, You, Dewen, Zhang, Shuodan, Wang, Jinhua, Arnovitz, Stephen, Elkahloun, Abdel, Price, Colles, Hong, Gia-Ming, Ren, Haomin, Kunjamma, Rejani B., Neilly, Mary Beth, Matthews, Jono, Xu, Mengyi, Larson, Richard A., Le Beau, Michelle M., Slany, Robert K., Liu, Paul P., Lu, Jun, Zhang, Jiwang, He, Chuan, Chen, Jianjun
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480215/
https://ncbi.nlm.nih.gov/pubmed/23079661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.08.028
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