Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

Small hairpin RNAs (shRNAs) having duplex lengths of 25–29 bp are normally processed by Dicer into short interfering RNAs (siRNAs) before incorporation into the RNA-induced silencing complex (RISC). However, shRNAs of ≤19 bp [short shRNAs (sshRNAs)] are too short for Dicer to excise their loops, rai...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Dallas, Anne, Ilves, Heini, Ge, Qing, Kumar, Pavan, Shorenstein, Joshua, Kazakov, Sergei A., Cuellar, Trinna L., McManus, Michael T., Behlke, Mark A., Johnston, Brian H.
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2012
נושאים:
RNA
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467060/
https://ncbi.nlm.nih.gov/pubmed/22810205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks662
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים