Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

Small hairpin RNAs (shRNAs) having duplex lengths of 25–29 bp are normally processed by Dicer into short interfering RNAs (siRNAs) before incorporation into the RNA-induced silencing complex (RISC). However, shRNAs of ≤19 bp [short shRNAs (sshRNAs)] are too short for Dicer to excise their loops, rai...

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Bibliografiske detaljer
Main Authors: Dallas, Anne, Ilves, Heini, Ge, Qing, Kumar, Pavan, Shorenstein, Joshua, Kazakov, Sergei A., Cuellar, Trinna L., McManus, Michael T., Behlke, Mark A., Johnston, Brian H.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467060/
https://ncbi.nlm.nih.gov/pubmed/22810205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks662
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