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Polymerase II Promoter Strength Determines Efficacy of microRNA Adapted shRNAs
Since the discovery of RNAi and microRNAs more than 10 years ago, much research has focused on the development of systems that usurp microRNA pathways to downregulate gene expression in mammalian cells. One of these systems makes use of endogenous microRNA pri-cursors that are expressed from polymer...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3198731/ https://ncbi.nlm.nih.gov/pubmed/22031824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026213 |
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