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Polymerase II Promoter Strength Determines Efficacy of microRNA Adapted shRNAs

Since the discovery of RNAi and microRNAs more than 10 years ago, much research has focused on the development of systems that usurp microRNA pathways to downregulate gene expression in mammalian cells. One of these systems makes use of endogenous microRNA pri-cursors that are expressed from polymer...

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Hlavní autoři: Lebbink, Robert Jan, Lowe, Maggie, Chan, Theresa, Khine, Htet, Wang, Xiaoyin, McManus, Michael T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198731/
https://ncbi.nlm.nih.gov/pubmed/22031824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026213
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