Polymerase II Promoter Strength Determines Efficacy of microRNA Adapted shRNAs

Since the discovery of RNAi and microRNAs more than 10 years ago, much research has focused on the development of systems that usurp microRNA pathways to downregulate gene expression in mammalian cells. One of these systems makes use of endogenous microRNA pri-cursors that are expressed from polymer...

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Bibliographic Details
Main Authors: Lebbink, Robert Jan, Lowe, Maggie, Chan, Theresa, Khine, Htet, Wang, Xiaoyin, McManus, Michael T.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198731/
https://ncbi.nlm.nih.gov/pubmed/22031824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026213
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