Minimal-length short hairpin RNAs: The relationship of structure and RNAi activity

Small hairpin RNAs (shRNAs) are widely used in RNAi studies and typically consist of a stem of 19–29 base pairs (bp), a loop of at least 4 nucleotides (nt), and a dinucleotide overhang at the 3′ end. Compared with shRNAs with 21–29 bp stems, we have found that shRNAs with 19-bp or shorter stems (ssh...

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Bibliografiska uppgifter
Huvudupphovsmän: Ge, Qing, Ilves, Heini, Dallas, Anne, Kumar, Pavan, Shorenstein, Joshua, Kazakov, Sergei A., Johnston, Brian H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802021/
https://ncbi.nlm.nih.gov/pubmed/19952116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1894510
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