Formulated Minimal-Length Synthetic Small Hairpin RNAs Are Potent Inhibitors of Hepatitis C Virus in Mice With Humanized Livers

Short synthetic small-hairpin RNAS (sshRNAs) (SG220 and SG273) that target the internal ribosome entry site of the hepatitis C virus (HCV) were formulated into lipid nano-particles and administered intravenously to HCV-infected urokinase plasminogen activator–severe combined immunodeficient mice wit...

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Detalhes bibliográficos
Main Authors: Ma, Han, Dallas, Anne, Ilves, Heini, Shorenstein, Joshua, MacLachlan, Ian, Klumpp, Klaus, Johnston, Brian H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896324/
https://ncbi.nlm.nih.gov/pubmed/24076507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.09.049
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