Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice

We previously identified short synthetic shRNAs (sshRNAs) that target a conserved hepatitis C virus (HCV) sequence within the internal ribosome entry site (IRES) of HCV and potently inhibit HCV IRES-linked gene expression. To assess in vivo liver delivery and activity, the HCV-directed sshRNA SG220...

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Detalhes bibliográficos
Main Authors: Dallas, Anne, Ilves, Heini, Shorenstein, Joshua, Judge, Adam, Spitler, Ryan, Contag, Christopher, Wong, Suet Ping, Harbottle, Richard P, MacLachlan, Ian, Johnston, Brian H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028017/
https://ncbi.nlm.nih.gov/pubmed/24045712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.50
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