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Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs

Small hairpin RNAs (shRNAs) with 19-base-pair, or shorter, stems (short shRNAs [sshRNAs]) have been found to constitute a class whose mechanism of action appears to be distinct from that of small interfering RNAs (siRNAs) or longer shRNAs. These sshRNAs can be as active as canonical siRNAs or longer...

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Main Authors: Ge, Qing, Dallas, Anne, Ilves, Heini, Shorenstein, Joshua, Behlke, Mark A., Johnston, Brian H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802022/
https://ncbi.nlm.nih.gov/pubmed/19948766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1901810
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