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Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs
Small hairpin RNAs (shRNAs) with 19-base-pair, or shorter, stems (short shRNAs [sshRNAs]) have been found to constitute a class whose mechanism of action appears to be distinct from that of small interfering RNAs (siRNAs) or longer shRNAs. These sshRNAs can be as active as canonical siRNAs or longer...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802022/ https://ncbi.nlm.nih.gov/pubmed/19948766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1901810 |
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