Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

Small hairpin RNAs (shRNAs) having duplex lengths of 25–29 bp are normally processed by Dicer into short interfering RNAs (siRNAs) before incorporation into the RNA-induced silencing complex (RISC). However, shRNAs of ≤19 bp [short shRNAs (sshRNAs)] are too short for Dicer to excise their loops, rai...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Dallas, Anne, Ilves, Heini, Ge, Qing, Kumar, Pavan, Shorenstein, Joshua, Kazakov, Sergei A., Cuellar, Trinna L., McManus, Michael T., Behlke, Mark A., Johnston, Brian H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2012
विषय:
RNA
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467060/
https://ncbi.nlm.nih.gov/pubmed/22810205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks662
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