Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth

FAK (focal adhesion kinase) and IGF-1R (insulin-like growth factor receptor-1) directly interact with each other and thereby activate crucial signaling pathways that benefit cancer cells. Inhibition of FAK and IGF-1R function has been shown to significantly decrease cancer cell proliferation and inc...

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Bibliografiske detaljer
Main Authors: Ucar, Deniz A., Kurenova, Elena, Garrett, Timothy J., Cance, William G., Nyberg, Carl, Cox, Audrey, Massoll, Nicole, Ostrov, David A., Lawrence, Nicholas, Sebti, Said M., Zajac-Kaye, Maria, Hochwald, Steven N.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466524/
https://ncbi.nlm.nih.gov/pubmed/22894899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21611
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