A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells

Melanoma has the highest mortality rate of all skin cancers and a major cause of treatment failure is drug resistance. Tumors heterogeneity requires novel therapeutic strategies and new drugs targeting multiple pathways. One of the new approaches is targeting the scaffolding function of tumor relate...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Kurenova, Elena, Ucar, Deniz, Liao, Jianqun, Yemma, Michael, Gogate, Priyanka, Bshara, Wiam, Sunar, Ulas, Seshadri, Mukund, Hochwald, Steven N, Cance, William G
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614818/
https://ncbi.nlm.nih.gov/pubmed/25486195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2015.941760
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