Targeting of the protein interaction site between FAK and IGF-1R

The interaction of focal adhesion kinase (FAK) and insulin-like growth factor-1 receptor (IGF-1R) plays an important role in cancer cell survival. Targeting this interaction with small molecule drugs could be a novel strategy in cancer therapy. By a series of pull-down assay using GST-tagged FAK fra...

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Huvudupphovsmän: Zheng, Donghang, Kurenova, Elena, Ucar, Deniz, Golubovskaya, Vita, Magis, Andrew, Ostrov, David, Cance, William G., Hochwald, Steven N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742998/
https://ncbi.nlm.nih.gov/pubmed/19664602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.07.156
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