A Novel Strategy to Inhibit FAK and IGF-1R Decreases Growth of Pancreatic Cancer Xenografts

Deregulation of insulin-like growth factor-1 receptor (IGF-1R) and focal adhesion kinase (FAK) signaling pathways plays an important role in cancer cell proliferation and metastasis. In pancreatic cancer cells, the crosstalk and compensatory mechanisms between these two pathways reduce the efficacy...

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Hlavní autoři: Zheng, Donghang, Golubovskaya, Vita, Kurenova, Elena, Wood, Cheng, Massoll, Nicole A., Ostrov, David, Cance, William G., Hochwald, Steven N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136037/
https://ncbi.nlm.nih.gov/pubmed/19885860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20590
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